Seizure Severity Prediction using Neutrophil-to-Lymphocyte and Plateletto-Lymphocyte Ratios Together with C-Reactive Protein in Idiopathic Epilepsy
Keywords:
Idiopathic epilepsy; seizure severity; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; C-reactive protein.Abstract
Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and C-reactive protein (CRP) are inflammatory biomarkers which may play a role in the activity and prognosis of many different diseases including epileptic seizures.
Seizure is a transient abnormal excessive hyper-synchronous neuronal activity in the brain which can present as a paroxysmal alteration of neurological functions, disturbance of consciousness, behavioral changes, cognition, emotion, motor or sensory dysfunction. The inflammation is a biological response of the immune system that can be triggered by various factors, including pathogens, damaged cells, and toxic compounds. Inflammation is a conserved evolutionary process characterized by the activation of immune and non-immune cells that protect the host from bacteria, viruses, toxins, and infections by eliminating pathogens and promoting tissue repair and restoration. The aim of the present study was to identify the inflammatory biomarkers: NLR, PLR and CRP as predictors of seizure severity in patients with idiopathic Epilepsy