An Overview on Misoprostol and Its Use in Myomectomy

Abstract

Background: Misoprostol is a synthetic prostaglandin E1 analog widely used in obstetrics and gynecology due to its uterotonic and cervical-ripening properties. It has established roles in medical termination of pregnancy, induction of labor, treatment and prevention of postpartum hemorrhage, and management of incomplete abortion. In addition, it is used in gastroenterology to prevent gastric ulcers in patients receiving nonsteroidal anti-inflammatory drugs (NSAIDs). Its low cost, ease of administration (oral, vaginal, sublingual, buccal, rectal), and stability at room temperature make it particularly valuable in resource-limited settings. However, its use requires careful dosing due to risks of hyperstimulation, uterine rupture, gastrointestinal side effects, and teratogenicity if pregnancy continues.