Role of Platelet Rich Fibrin Glue in Vesicovaginal Fistulas

Abstract

Vesicovaginal fistula (VVF) remains one of the most distressing complications of gynecological and obstetric procedures. Traditional surgical repairs, such as the Martius flap, are effective but associated with longer operative time and donor-site morbidity. Platelet-rich fibrin (PRF) glue, a second-generation autologous platelet concentrate, provides a three-dimensional fibrin matrix enriched with platelets and leukocytes, enabling controlled release of growth factors. This enhances tissue regeneration, angiogenesis, and wound healing, making PRF a promising alternative as an interposition layer in VVF repair.