An Overvie on Application of Platelet Rich Plasma in Chronic Diabetic Foot Ulcer

Abstract

PRP therapy involves the centrifugation of autologous blood to concentrate platelets, which are then activated to release growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and transforming growth factor-beta (TGF-β). These factors play a pivotal role in stimulating cell proliferation, collagen synthesis, and tissue regeneration. Initially developed in the 1970s for hematologic applications, PRP has since expanded into multiple medical specialties. However, the lack of standardized preparation methods and inconsistent clinical trial results have led to debates regarding its true therapeutic potential.