Role of Pitutary Adenylated Cyclase Activating Polypeptide in Multiple Myeloma

Authors

  • Arwa Osama Mahmoud El-bayaa, Saad Sabry El-Osh, Marwa Mohammed Esawy, Ahmed Mokhtar Ahmed, Ayman Fathy Abd El-Halim

Keywords:

PACAP, multiple myeloma, neuropeptides, bone marrow microenvironment, immunomodulation, apoptosis.

Abstract

Background: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a multifunctional neuropeptide with immunomodulatory, anti-inflammatory, and cytoprotective effects. Emerging evidence suggests that PACAP may influence tumor biology through regulation of proliferation, angiogenesis, apoptosis, and immune surveillance. In hematological malignancies such as multiple myeloma (MM), where the bone marrow microenvironment plays a critical role in disease progression, PACAP signaling may represent a novel modulatory axis.

Published

2024-09-30

How to Cite

Arwa Osama Mahmoud El-bayaa. (2024). Role of Pitutary Adenylated Cyclase Activating Polypeptide in Multiple Myeloma . The International Journal of Multiphysics, 18(3), 3096 - 3103. Retrieved from https://themultiphysicsjournal.com/index.php/ijm/article/view/1933

Issue

Vol. 18 No. 3 (2024)

Section

Articles

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