Relationship between Hepatitis C Virus Infection and Peripheral Neuropathy

Abstract

Background: Hepatitis C virus (HCV) infection is a major global health problem, affecting approximately 58 million people worldwide. While its primary target is the liver, HCV is increasingly recognized as a systemic disease with a wide spectrum of extrahepatic manifestations. One of the most clinically relevant complications is peripheral neuropathy, which may arise due to direct viral neurotropism, immune-mediated mechanisms, or metabolic alterations. Peripheral neuropathy in HCV patients often manifests as sensory disturbances, pain, or motor deficits, significantly impacting quality of life and long-term prognosis. Understanding this relationship is essential for early recognition, targeted management, and improved patient outcomes.