Heart Failure in Children with Congenital Heart Disease

Abstract

Background: In the contemporary Western world, heart failure (HF) is one of the leading causes of hospitalization and death, the cause of heart failure in children may be pressure overload or volume overload or both. The most common cause of heart failure in infancy is CHD. Despite the fact that HF therapy has improved prognosis and quality of life, death is still relatively high. Neurohormonal inhibition of an overactive neurohormonal axis is the medical therapy approach. In terms of hospitalization, mortality, and the course of the disease, no one sign has been able to predict or track HF. As the molecular signatures of CHD and HF are being characterized with the use of available technology, it is increasingly appreciated that at least some disease pathways are shared. Determining the molecular basis of HF in CHD will play a crucial role in developing treatment strategies for this growing population. It is necessary to develop new techniques for prognosis, therapeutic monitoring, and diagnosis.

Conclusion: The most common cause of heart failure in infancy is congenital heart disease.