Investigating of Occlusion Methods and their Impact on the Prostate Health and Blood Biochemical Parameters in Adult Male Rabbits

Abstract

The prostate is a critical organ in the male reproductive system, essential for seminal fluid and sperm production. This study investigates the effects of blood flow occlusion on prostate size, prostate-specific antigen (PSA) levels, and biochemical parameters in adult male rabbits. Twenty rabbits were randomly assigned to four groups: prostate occlusion, proprostate occlusion, paraprostate occlusion, and a control group. Prostate gland sampling was performed on days 30 and 60 post-surgery, and data were analyzed using SPSS software.

Results demonstrated a significant increase in PSA levels in all occlusion groups, with the highest levels in the prostate occlusion group, suggesting stimulation and functional changes within the gland. Pre- and postoperative measurements showed a marked increase in prostate size among occlusion groups, likely due to inflammation and histopathological changes caused by reduced blood flow. Biochemical analyses revealed elevated liver enzyme levels (ALT and AST), particularly in the prostate occlusion group, indicating liver damage and systemic inflammation. Complete blood count (CBC) analysis showed increased white blood cell (WBC) counts in the occlusion groups, reflecting an immune response and potential systemic inflammation.

These findings reveal that blood flow occlusion significantly affects prostate health, liver function, and systemic physiology. The observed changes in PSA and liver enzyme levels resemble alterations seen in prostate cancer or benign prostatic hyperplasia (BPH) patients, underscoring the potential of occlusion as a therapeutic approach and the need for further clinical studies.