Evaluating the Effects of Alpha-Lipoic Acid Treatment on Experimentally Induced Cataracts in Rabbit Model by Ultrasonography and Slit Lamp Examination

Abstract

Background and Objective: Cataracts refers to an optical condition associated with turbidity and cloudiness of the lens. It is a slow-progressing disease and ultimately results in diurnal and/or nocturnal vision impairment. Alpha-lipoic Acid (ALA) is a potent anti-oxidant agent used to assist to impede the progress of hepatic conditions, such as hepatitis, and fatty liver disease. Given the great potency of this compound as an antioxidant, it is possible that ALA can be more efficient than vitamin E in halting the progress of cataractss. This study intends to evaluate the effects of ALA treatment on experimentally induced cataractss in rabbit models by methods of ultrasonography and slit lamp examination.

Design: A total number of 18 rabbits were assigned to three groups (n=6): a) ALA, b) positive control, and c) negative control. Each group was followed up for 20 days and the incidence of cataracts and its grade was recorded independently.

Findings: While the highest grade of cataracts recorded for ALA treated group was grade 1, grade 2 and grade 3 cataractss were present in positive control and negative control groups.

Conclusions: ALA is effective in preventing the progression of cataractss to later stages and protecting the lens from further damage.